Scientist Computational Chemistry - Brussel

Function Group: R&D / Chemistry Scientist

Organization

For a young and innovative drug discovery company, we are looking for a Scientist Computational Chemistry. Since their start in 2015, they have quickly developed into a stable biotechnology company, that is quickly expanding their activities. Their mission is to discover and develop new therapies and drugs for severe and neglected diseases. Their unique antibody technology allows for stabilising and researching “undruggable” membrane proteins, which opens a whole new world of possibilities for drug discovery screening.

Function

In this position within the structural biology group, you will be the expert in your field. You will bring new capabilities for the further successful development of their drug discovery activities. Therefore you will be working closely together with different stakeholders, such as the Structural Biologists, the Chemists and the Antibody scientists.

  • Play a key role in structure or ligand-based drug discovery projects, by providing expertise and support
  • Introduce computational/modelling chemistry methodologies (Schrödinger (or equivalent), MOE and Dotmatics products)
  • Effectively utilise structural information, molecular modeling techniques, in silico prediction models, chemical library design, as well as data mining.
  • Design of (bio)molecules and virtual libraries
  • Work closely with collaborators and other members of the drug discovery group to drive programs and our technology forward
  • Opportunity to work as a Project Leader
  • Presentation of complex scientific data

Requirements

You will bring the following skill set/experience:

  • Ph.D. (or equivalent) in (computational) chemistry
  • More than three years of relevant industrial experience, with a track record in drug discovery projects
  • Thorough knowledge of programming/scripting languages or chemically aware databases
  • Previous experience in designing compounds in a 3D structure-based environment
  • Knowledge on small molecule conformations, ionisation/tautomeric states and protein-ligand interactions
  • Ability to work independently, prioritise, bring new ideas and adapt activities
  • Strong communication/collaboration skills with scientist in different fields
  • Previous experience in modelling areas such as:
  1. Structure/ligand/fragment-based design cheminformatics
  2. Virtual ligand screening
  3. Computationally-driven lead optimisation
  4. Ligand-based drug design
  5. Molecular dynamics
  6. Homology modeling
  7. Quantum mechanics
  8. Cheminformatics or ADMET/QSPR

Offer

You may expect:

  • Joining a quickly growing biotech company with a unique drug discovery approach
  • Work multidisciplinary, from small molecules, over antibodies up to membrane proteins
  • High level of independency in your work
  • Broad scope of activities
  • Chance to grow further along with the company
  • A competitive salary and benefits package

Application

If you are interested in this job, or in similar ones, please feel free to contact me directly.

Lorin Raats
Consultant R&D | Biotechnological and Pharmaceutical Industry

+31(0)6-30238143
l.raats@qtcrecruitment.com

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