(Senior) Scientist Structural Biology / Crystallography - Ghent

Vacancy information

Publication date:June 03 2020
Employment type:Permanent
Function Group:R&D

Function Group: R&D / Biology Senior Scientist


For one of the up-and-coming European biotech companies, we are looking for a Senior Scientist Antibody Discovery with line management responsibilities. This company, created in 2015, has developed into a stable biotechnology company and they are quickly expanding their activities. Their mission is to discover and develop new therapies and dugs for severe and neglected diseases. Their unique antibody technology allows for stabilising and researching “undruggable” membrane proteins, which opens a whole new world of possibilities for drug discovery screening. Therefore they are looking for a Scientist that can take the lead in new Structural Biology projects, which will allow the development of new small molecule drugs.


You will join the Structural Biology group, which is key to the success of the organisation and consists of specialists in the GPCR field. The company has heavily invested in this group and therefore you will be able to use all state-of-the-art technologies, including cryo-em. As (Senior) Scientist, you will set-up your own projects in the broader company strategy and guide one or two Research Associates. You will be able to quickly develop yourself in a fast-growing group and under the guidance of a Manager with extensive academic and industry experience.

With your expertise in the field, you will quickly bring value to the current programs. You will not only be working as a Structural Biologist, you will also be Project Member in broader drug discovery programs and have the opportunity to work as a Project Leader yourself. Thus you will see the whole drug discovery process inside the company from a to z!

  • Cloning of membrane protein plasmid constructs and expression in insect and mammalian cells
  • Characterisation of expression levels in membrane and in solubilised form
  • Construct engineering to optimise expression and/or protein stability
  • Characterisation of protein stability in solubilised form
  • Biophysical, X-ray and EM experiments
  • Coaching of Research Associates
  • Core member of project teams
  • Project leader role in drug discovery projects


In this position, you bring the following skills-set/experience:

  • PhD or equivalent experience in a related field
  • More than three years of experience as post-doc or in a company
  • Purification, sample preparation, design and implementation of crystallisation trials
  • Crystal optimisation techniques for membrane proteins
  • Data collection and interpretation of X-ray crystallography co-structure data
  • Highly collaborative, self-motivated, dynamic and team-oriented individual

Bringing protein biophysical characterisation (thermostability, (F-)SEC and/or IR,), screening (SPR and/or thermal shift) and cryo-em knowledge is a plus.


You may expect:

  • Joining a quickly growing biotech company with a unique drug discovery approach
  • Work multidisciplinary both as a Project Member as well as Project Leader of drug discovery project
  • High level of independency in your work, combined with coaching responsibilities
  • Expand your skillset under supervision of experts in the field
  • Opportunity to work with all state-of-the-art technologies
  • Chance to grow further along with the company
  • A competitive salary and benefits package


If you are interested in this job, or in similar ones, please feel free to contact me directly.

Lorin Raats
Consultant R&D | Biotechnological and Pharmaceutical Industry




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